Synthetic Studies in the Field of Natural Product Chemistry

合成有机计划支持Yoshito的工作 岸 哈佛大学化学教授岸信夫是 参与了一个基础广泛的天然产品项目， 化学. 其中包括继续开展综合工作， 最复杂的有机化合物之一 知道的 由于这些努力， 研究复杂分子的形状， 关于控制形状的因素的基本问题 糖正在开发中。 新的方法来理解 生物发光现象与化合物合成 自然生物发光的原因 进行。 这项工作的主要目标是使重要的 对有机化学的贡献 八个研究课题，包括： 海葵毒素，海葵毒素局部构象分析，海葵毒素 C-和O-糖苷的构象分析，制备 螺旋寡肽化学，生物发光 甲藻和磷虾系统的化学 蘑菇系统的生物发光。

The Synthetic Organic Program supports the work of Yoshito Kishi. Kishi, Professor of Chemistry at Harvard University, is involved with a broadly based program of natural products chemistry. Included is a continuation of work on the synthesis of palytoxin, one of the most complicated organic compounds known. As a consequence of these efforts, new approaches to examine the shapes of complex molecules, and answers to fundamental questions about factors controlling the shapes of sugars are being developed. New methods for understanding the phenomena of bioluminescence and syntheses of compounds responsible for natural bioluminescence are also being undertaken. The major objective of this work is to make significant contributions to organic chemistry through investigations into eight research topics including: the total synthesis of palytoxin, the local conformational analysis of palytoxin, the conformational analysis of C- and O- glycosides, preparation and chemistry of helical oligopeptides, bioluminescence chemistry of dinoflagellate and krill systems and the bioluminescence of mushroom systems.