Regulation of Gene Expression During Sporulation of BacillusSubtilis

细菌孢子形成是细胞分化的原始系统。一项系统的研究旨在鉴定和研究芽胞形成过程中所需的必需营养基因的作用，并将必需基因的信息与我们对枯草杆菌SPO基因的了解相结合。这项研究将集中在SPIIA，它编码一种RNA聚合酶西格玛因子，以及可能参与孢子隔形成的基因。有人建议寻找直接或间接受spIIA控制的必需基因，并扩大搜索范围，以包括与产孢子开始相关的sp0H控制的必需基因。控制两个营养分裂基因ftsa和ftsZ的基因将被分析为孢子形成过程中可能需要的必要基因的原型。

Bacterial spore formation is a primitive system of cellular differentiation. A systematic study is proposed aimed at identifying and investigating the roles of essential vegetative genes that are needed during spore formation, and at integrating information about essential genes with our knowledge of spo genes in the bacterium Bacillus subtilis. The study will focus on spoIIA, which codes for an RNA polymerase sigma factor, and genes that are likely to be involved in spore septum formation. It is proposed to search for essential genes that are directly or indirectly under the control of spoIIA, and to extend the search to include essential genes under the control of spoOH, which is associated with the start of sporulation. The Controls of two vegetative division genes, ftsA and ftsZ, will be analyzed as likely prototypes of essential genes that are needed during sporulation.