Synaptic Inputs to Supraoptic Nucleus

大细胞神经内分泌系统是下丘脑一个非常重要的区域，通过催产素控制分娩时子宫收缩、泌乳反射和母体行为，并通过加压素调节体液稳态、血管收缩、应激反应，可能还包括记忆。催产素和抗利尿激素的释放是由这些大细胞神经元的活动控制的。Weiss博士将在正常动物中识别这些神经元的输入，因为传入事件很可能在决定它们的活动方面起着关键作用。然后，他将研究哺乳和缺水对这些突触输入的影响。识别生理刺激后的突触可塑性将极大地有助于我们了解大脑如何组织活动和维持我们的重要功能。鉴于下丘脑与体液平衡和心血管系统调节的关系，基础研究可能有助于更好地了解高血压和心脏病的神经调节，这些疾病是我们社会中年男性死亡的主要原因。

The magnocellular neuroendocrine system is a very important region of the hypothalamus which is involved in control of uterine contractions during parturition, the milk let-down reflex, and maternal behavior via oxytocin as well as the regulation of fluid homeostasis, vasoconstriction, stress responses, and possibly memory via vasopressin. The release of oxytocin and vasopressin are governed by the activity of these large magnocellular neurons. Dr. Weiss will identify the inputs to these neurons in normal animals since it is likely that the afferents play an critical role in determining their activity. He will then examine the influence of lactation and water deprivation on these synaptic inputs. Discerning the synaptic plasticity following physiological stimuli will contribute greatly to our knowledge of how the brain organizes actions and maintains our vital functions. Given the relationship of this hypothalamic region to regulation of fluid balance and the cardiovascular system, basic research may lead to better understanding of the neural regulation of hypertension and heart disease which are a major cause of death in middle-age males in our society.