Organic Synthesis via Transition

这项研究得到了有机合成的支持。 程序. Hegedus博士将继续他的发展， 过渡金属基试剂作为高选择性合成 工具. 这项研究的科学意义在于， 有机合成中常用的化学变换 将被开发，新的有机化合物与有趣的 将产生物理、生物和化学性质， 有效的合成方法， 将开发杂环和碳环系统。 研究的总体目标是开发新的 使用过渡金属络合物的合成方法 有机官能团的新反应模式。 这 将通过仔细研究基础化学 所涉及的金属有机物种，以允许 开发有用的新合成转化。 的 新开发的工艺将应用于合成 尽可能的合成分子。 反应性有机 中间体如富电子烯酮，手性烯酰胺， 高度官能化的手性四元中心，和 “推拉式”艾伦，将成为日常访问， 可用于通过由金属络合物生成它们来合成。 新开发的方法将用于综合 手性生物活性β-内酰胺（+）-硫霉素 用于掺入大环化合物中的叔醇 抗生素和聚醚类抗生素，三喹， 吡咯并吲哚醌。

This research is being supported by the Organic Synthesis Program. Dr. Hegedus will continue his development of transition metal based reagents as highly selective synthetic tools. The scientific significance of the research is that new chemical transformations of general use for organic synthesis will be developed, that new organic compounds with interesting physical, biological, and chemical properties will be produced, and that efficient synthetic approaches to a variety of heterocyclic and carbocyclic systems will be developed. The overall objective of the research is to develop new synthetic methods using transition metal complexes to permit new modes of reactivity for organic functional groups. This will be achieved by careful study of the fundamental chemistry of the metal-organic species involved, to permit the development of useful, new synthetic transformations. The newly developed processes will be applied to the synthesis of complex molecules when possible. Reactive organic intermediates such as electron-rich ketenes, chiral enamides, highly functionalized chiral quarternary centers, and "push-pull" allenes, will be made routinely accessible and usable for synthesis by generating them from metal complexes. The newly developed methodology will be used to synthesize the biologically active beta-lactam (+)-thienamycin, chiral tertiary alcohols for incorporation into macrocyclic antibiotics and polyether antibiotics, triquinanes and pyrroloindoloquinones.