Biomolecular condensates in mRNA-regulation in germ cells

该项目旨在研究细胞如何形成富含特定生物功能的微环境。该项目将尖端的体外和体内实验相结合，将在新兴的液-液相分离领域产生新的知识。我们将分析生育所需的胚芽颗粒的形成。预期的结果是对细胞中液-液相分离如何发生的变革性理解，从长远来看，这将在生物技术和疾病治疗中得到应用。

This project aims to investigate how cells form microenvironments that are enriched for specific biological functions. Using a powerful combination of cutting-edge in vitro and in vivo experiments, the project will generate new knowledge in the emerging area of liquid-liquid phase separation. We will analyse the formation of germ granules that are required for fertility. The expected outcome is a transformational understanding of how liquid-liquid phase separation occurs in cells which, in the longer term, will have applications in biotechnology and disease treatment.