Long & Medium Term Research: A Study of Adsorbed Protein Interactions Using the Surface Force Apparatus

长期中期研究：吸附蛋白质的研究 使用表面力装置的相互作用 该奖项是根据长期计划提出的。 &在国外卓越中心的中期研究。 的 该计划旨在使美国科学家和工程师能够 在国外的研究机构进行长期研究， 证明卓越。 奖项提供了机会， 开展联合研究，以及使用独特或 免费设施、专业知识和实验条件 在国外 该奖项将支持罗伯特·D博士为期12个月的访问。 蒂尔顿去瑞典与博士工作。 表面化学研究所的“吸附研究” 使用表面力装置的蛋白质相互作用。“博士。 蒂尔顿计划用表面力装置来测量 力-距离关系表征了 吸附蛋白质所经历的分子间相互作用。 有了这项最近开发的技术，小到 10的负7次方N是在相对交叉之间测量的 云母圆柱体，分离度小于1 nm。 表面力仪器的极端灵敏度使得 它有助于研究支配行为的力量 分子和胶体系统。 这种方法 特别适用于表征非DLVO力，例如 排斥水化和吸引疏水力， 在生物和胶体系统中很重要。 使用 表面力仪定量研究 吸附的蛋白质与 表面和其他生物分子将改善我们的 对蛋白质驱动的基本现象的理解 吸附，从而将有助于发展 接触生物环境的材料。 授标建议提供资金， 适当的，国际旅行，出国当地旅行， 津贴，家属津贴（如适用）和公寓 美国本土机构的行政津贴为250美元。

Long & Medium-Term Research: A Study of Adsorbed Protein Interactions Using the Surface Force Apparatus This award recommendation is made under the Program for Long & Medium-Term Research at Foreign Centers of Excellence. The program seeks to enable US scientists and engineers to conduct long-term research abroad at research institutions of proven excellence. Awards provide opportunities for the conduct of joint research, and the use of unique or complimentary facilities, expertise and experimental conditions in foreign countries. This award will support a 12 month visit by Dr. Robert D. Tilton to go to Sweden to work with Dr. Per Claesson of the Institute for Surface Chemistry on "A Study of Adsorbed Protein Interactions Using the Surface Force Apparatus." Dr. Tilton plans to use the surface force apparatus to measure the force-distance relationships characterizing the intermolecular interactions experienced by adsorbed proteins. With this recently developed technique, forces as small as 10-to-the-minus-7 N are measured between opposing crossed mica cylinders at separations resolvable to less than 1nm. The extreme sensitivity of the surface force apparatus makes it useful in the study of the forces that govern the behavior of molecular and colloidal systems. This approach is especially useful to characterize non-DLVO forces, such as repulsive hydration and attractive hydrophobic forces, that are important in biological and colloidal systems. Use of the surface force apparatus to quantitatively study the character of the interactions of adsorbed proteins with surfaces and with other biomolecules will improve our understanding of the basic phenomena driving protein adsorption, and thus will assist in the development of materials that contact the biological environment. The award recommendation provides funds to cover, as appropriate, international travel, local travel abroad, stipend, dependents' allowance if applicable, and a flat administrative allowance of $250 for the U.S. home institution.