Regulation of lung immune-epithelial networks sensing environmental change

本研究旨在揭示肺上皮细胞如何与免疫细胞结合，并确定其细胞和分子连接，以确保肺组织的稳态维持和必要的修复过程。维持肺上皮免疫网络对于维持正常的肺组织结构和功能，以及诱导免疫反应以防止微生物攻击或吸入潜在有毒物质至关重要。了解上皮免疫细胞介导的感知/修复的分子程序对于理解组织修复过程如何在肺中驱动至关重要，肺是呼吸和生命的关键器官。

This study aims to uncover how lung epithelial cells engage with immune cells and determine their cellular and molecular wiring to ensure homeostatic maintenance and essential repair processes of lung tissues. Maintenance of lung epithelial-immune networks is essential to maintain normal lung tissue structure and function, and to induce immune responses to protect against microbial challenges or inhaled potentially toxic substances. Understanding this molecular program of epithelial-immune cell-mediated sensing/repair will be essential to understand how tissue-repair processes can be driven in the lung, an organ critical for respiration and thus life.