RUI: Ontogeny of Modulation of Dentate Granule Cell Excitability in the Freely-moving Rat

这是一个RUI建议， 神经生理学研究的工程专业学生。 的 项目是记录海马体的细胞， 断乳前后自由活动大鼠 时期 对成对电刺激的反应 将被用来描述 易化和抑制调制的研究 细胞 拟议项目的独特之处在于， 可以获得行为的神经生理学相关性 通过使用未麻醉和自由移动的动物。 这项研究将使人们更好地了解 成熟的基本生理学，它也将 让工科大学生参与到重要的生活中 科学研究。

This is a RUI proposal to involve undergraduate engineering students in neurophysiology research. The project is to record from cells of the hippocampus of freely-moving rats during the preweaning and postweaning periods. The responses to paired electrical stimulation will be used to characterize the development of facilitatory and inhibitory modulation of the studied cells. The proposed project is unique in that neurophysiological correlates of behavior can be obtained by the use of unanesthetized and freely moving animals. The research will lead to an improved understanding of the basic physiology of maturation, and it will also involve engineering undergraduates in significant life sciences research.