The Design of Chiral Lewis Acids and Chiral Silane Reagents

该奖项将支持科罗拉多大学博尔德分校的Tarek Sammakia博士的研究。该奖项是Sammakia博士化学博士后研究奖学金的初始授予部分，涉及手性Lewis酸和手性硅烷试剂的设计、合成和反应性。将合成稳定的α-二茂铁基Lewis酸性碳正离子，其手性中心位于活性碳正离子表面下方。这些活性中间体将被评价为Aldol缩合反应、Michael加成反应和Diels-Alder反应中的立体生成中心。二茂铁模板还将被用于合成手性二茂铁基硅烷，这将在酮的不对称还原中进行测试。

This award will support the research of Dr. Tarek Sammakia at the University of Colorado at Boulder. The award is the starter grant portion of Dr. Sammakia's Postdoctoral Research Fellowship in Chemistry and deals with the design, synthesis, and reactivity of chiral Lewis acids and chiral silane reagents. Stable alpha-ferrocenyl Lewis acid carbocations will be synthesized which have a chiral center below the face of the reactive carbonium center. These reactive intermediates will be evaluated as the stereogenic centers in aldol condensations, Michael addition reactions and Diels-Alder reactions. The ferrocene template will also be used to synthesize chiral ferrocenyl silanes which will be tested in the asymmetric reduction of ketones.