U.S.-Italy Cooperative Research: Swellable Controlled Release Polymeric Systems With or Without Dissolution

该奖项将支持普渡大学的尼古拉斯·佩帕斯教授 与Paolo教授合作研究的大学 意大利帕尔马大学的科隆博。 研究人员 打算调查造成这一现象的机制， 水溶性肽的转运和释放 多孔亲水聚合物。 聚合物/肽系统 研究包括未交联的聚（乙烯醇）， 聚（丙烯酸）、羟丙基甲基纤维素和 各种聚甲基丙烯酸酯。 扩散和释放研究 将使用降钙素、曲唑酮、双氯芬酸， 地尔硫卓和哌唑嗪。 溶胀型控释系统是一种 用于释放药物的有前途的新类型的聚合物系统 和生物分子。 尽管它们释放小分子的能力 分子在恒定速率下的运动已经通过以前的实验证明， 研究，尚未对高释放进行研究。 分子量（75，000）大分子。 明显的应用 这项研究的一部分将是在基因释放领域， 在目标区域设计分子。 拟议的工作将 提供了对耦合现象的重要理解 扩散/膨胀/溶解，并将提供指导方针 用于开发更好的控制释放系统。

This award will support Professor Nikolaos Peppas of Purdue University in a research collaboration with Professor Paolo Colombo of the University of Parma, Italy. The researchers intend to investigate the mechanisms responsible for the transport and release of water soluble peptides from non- porous, hydrophilic polymers. Polymer/peptide systems to be investigated include uncrosslinked poly(vinyl alcohol), poly(acrylic acid), hydroxypropyl methyl cellulose and various polymethacrylates. Diffusion and release studies will be performed with calcitonin, trazodone, diclofenac, diltiazem and prazosin. Controlled release systems of the swelling type are a promising new class of polymeric systems for release of drugs and biomolecules. Although their capability to release small molecules at constant rates has been proven through previous studies, no study has been done yet for the release of high molecular weight (75,000) macromolecules. Obvious applications of this research will be in the area of release of genetically engineered molecules in target areas. The proposed work will provide an important understanding of the coupled phenomena of diffusion/swelling/dissolution and will offer guidelines for the development of better controlled release systems.