Mechanisms of DNA Repair and Mutagenesis in Plants

在修复中有缺陷的拟南芥突变体 紫外线引起的DNA损伤的可能性。 遗传分析将用于阐明分子机制 逆转或修复损伤所需的各种途径 并确定哪些修复途径参与其中。 重组缺陷的突变体也可以被预期为 因为许多基本的细胞机制也利用了 修复路径。突变体鉴定后， 将继续进行有关基因的克隆。 这种模式生物的DNA修复突变体的可用性将 加强对植物这一重要研究领域的研究。*

Mutants of Arabidopsis thaliana which are defective in the repair of DNA damage induced by ultraviolet light will be isolated. Genetic analysis will be used to elucidate the molecular mechanism of the various pathways required for reversal or repair of damage to DNA and determine which of the repair pathways are involved. Mutants defective in recombination can be expected to also be isolated since many basic cellular mechanisms also utilize the repair pathways. After mutant characterization, strategies for cloning the involved genes will be pursued. The availability of DNA repair mutants of this model organism will enhance studies of this important area of research in plants.***