The Role of Antifreeze Proteins in Freezing Avoidance of Antarctic Fishes

南极鱼生活在常年结冰的沃茨 体液点。 这些沃茨将没有鱼， 这些鱼没有进化出生物抗冻分子来避免 冻死了 南极防冻剂的演变 鱼类具有相当大的科学价值。 亚瑟·德弗里斯博士 他开始研究南极鱼的防冻剂， 几十年前，他系统地研究了这一机制， 其防冻剂使整个动物避免受冻。 本研究项目将继续研究防冻剂如何 通过研究南极鱼类的生理和 与抗冻性有关的机械过程。 生理学研究包括防冻剂和因子的合成 控制合成、分泌、液体和组织运输， 防冻剂的保存。 机制研究的重点是 了解防冻剂如何吸附到冰和抑制冰晶 增长 除了项目的内在价值，冻结 鱼类的回避可能会对人类的领域产生影响， 病理学、成核理论和晶体学。

Antarctic fish live in waters that are perennially at the freezing point of body fluids. These waters would be devoid of fish if these fish had not evolved biological antifreeze molecules to avoid freezing. The evolutionary aspects of antifreezes in Antarctic fish possess considerable scientific interest. Dr. Arthur DeVries began his studies on antifreezes in Antarctic fish over three decades ago and has systematically investigated the mechanism by which antifreezes confer freezing avoidance on the whole animal. This research project will continue the study of how antifreezes evolved in the Antarctic fishes by examining the physiological and mechanistic processes involved in freezing tolerance. Physiological studies include synthesis of antifreezes and factors that govern synthesis, secretion, fluid and tissue transport, and conservation of antifreezes. Mechanistic studies focus on understanding how antifreezes adsorb to ice and inhibit ice crystal growth. Aside from the intrinsic value of the project, freezing avoidance in fish could have implications to the fields of human pathologies, in nucleation theory, and in crystallography.