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Mechanisms of action of antiestrogens: towards improved treatment of relapse in ER+ breast cancer

Mechanisms of action of antiestrogens: towards improved treatment of relapse in ER+ breast cancer
抗雌激素的作用机制:改善 ER 乳腺癌复发的治疗
批准号:
372071
负责人:
Mader Sylvie N
金额:
$54.34万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2017
资助国家:
加拿大
项目状态:
已结题
起止时间:
2017-09-01 至 2022-09-01

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中文摘要
翻译
乳腺癌是加拿大妇女中最常见的癌症,也是癌症死亡的第二大原因。雌激素通过一种特殊的效应物雌激素受体(ER)参与乳腺肿瘤的发生,雌激素受体存在于2/3的乳腺肿瘤中
英文摘要
Breast cancer is the most frequently diagnosed cancer and second leading cause of cancer death among Canadian women. Estrogens contribute to breast tumorigenesis by acting via a specific effector, estrogen receptor alpha (ER), present in 2/3 breast tumors
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会议论文
Mechanisms of action of antiestrogens in breast cancer: roles of ubiquitin-like modifications in transcriptional inactivation of Estrogen Receptor alpha.
  • 批准号:
    480045
  • 项目类别:
    Operating Grants
  • 资助金额:
    $61.3万
  • 财政年份:
    2023
  • 负责人:
    Mader Sylvie N
  • 依托单位:
Mechanisms of action of antiestrogens in breast cancer: roles of Ubi-like modifications in transcriptional inactivation of Estrogen Receptor alpha.
  • 批准号:
    472352
  • 项目类别:
    Operating Grants
  • 资助金额:
    $7.29万
  • 财政年份:
    2022
  • 负责人:
    Mader Sylvie N
  • 依托单位:
Mechanisms controlling estrogen receptor alpha expression and activity in breast tumorigenesis
  • 批准号:
    358549
  • 项目类别:
    Operating Grants
  • 资助金额:
    $66.32万
  • 财政年份:
    2016
  • 负责人:
    Mader Sylvie N
  • 依托单位:
Mechanisms of action of full antiestrogens
  • 批准号:
    268027
  • 项目类别:
    Operating Grants
  • 资助金额:
    $50.72万
  • 财政年份:
    2012
  • 负责人:
    Mader Sylvie N
  • 依托单位:
海外基金