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INTEGRative multi-OMICs approaches on iPSC-derived 2D and 3D models to elucidate the role of immune and energy metabolism related genes/pathways in Amyotrophic Lateral Sclerosis

INTEGRative multi-OMICs approaches on iPSC-derived 2D and 3D models to elucidate the role of immune and energy metabolism related genes/pathways in Amyotrophic Lateral Sclerosis
对 iPSC 衍生的 2D 和 3D 模型进行综合多组学方法,以阐明免疫和能量代谢相关基因/途径在肌萎缩侧索硬化症中的作用
批准号:
387428
负责人:
Stifani Stefano
金额:
$10.93万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2018
资助国家:
加拿大
项目状态:
已结题
起止时间:
2018-06-01 至 2021-06-01

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中文摘要
翻译
ALS是最常见的运动神经元疾病。其特征在于脑和脊髓中运动神经元(MN)的死亡。这种疾病开始于成年生活,并导致进行性瘫痪,通常在几年内致命,通常是由于
英文摘要
ALS is the most common motor neuron disease. It is characterized by the death of motor neurons (MNs) in the brain and spinal cord. The disease starts in adult life and causes a progressive paralysis that is typically fatal within a few years, usually due
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会议论文
Regeneration of motor neurons controlling movement and respiration from embryonic stem cells
  • 批准号:
    253876
  • 项目类别:
    Operating Grants
  • 资助金额:
    $48.41万
  • 财政年份:
    2012
  • 负责人:
    Stifani Stefano
  • 依托单位:
Regulation of motor neuron identity and circuit development
  • 批准号:
    253137
  • 项目类别:
    Operating Grants
  • 资助金额:
    $54.41万
  • 财政年份:
    2012
  • 负责人:
    Stifani Stefano
  • 依托单位:
Transcriptional regulation of proliferation and self-renewal in glial progenitors and glioblastoma stem-like cells
  • 批准号:
    231936
  • 项目类别:
    Operating Grants
  • 资助金额:
    $7.29万
  • 财政年份:
    2011
  • 负责人:
    Stifani Stefano
  • 依托单位:
海外基金