US-Czechoslavakia Spectroscopic Conformational Studies of Proteins

此次美国之行的主要目标-捷克斯洛伐克研究 大学的蒂莫西·凯德林博士 查尔斯大学的Petr Pancoska博士 以确定可靠的经验解释， 二级结构的蛋白质光谱数据。 的 研究人员将使用各种振动光谱， 包括圆二色性。 的组合 技术旨在利用每种技术的优势， 对光谱数据进行统一的系统分析。 用于校准分析的参考蛋白 方法将是那些良好的晶体结构 数据是可用的。 聚类分析与神经网络 分析将被用来澄清相互关系 初始结构参数。 结果将 链接到一个优化的单一计算模型。 的 希望使用这样的标准模型 光谱数据处理将简化对 大量关于蛋白质的新文献 特征化 本课题在实验物理化学方面实现了 以增进科学知识为规划目标 通过让美国的顶尖研究人员， 东欧将联合收割机互补人才， 共同感兴趣的领域的研究资源， 能力。

The primary objective at this U.S.-Czechoslovakia research project between Dr. Timothy Keiderling of the University of Illinois and Dr. Petr Pancoska of Charles University is to determine reliable empirical interpretations of protein spectroscopic data for secondary structure. The researchers will employ various vibrational spectroscopies, including circular dichroism. The combination of techniques is intended to draw upon strengths of each to produce uniform systematic analysis for spectral data. The reference proteins used to calibrate the analytical methods will be those for which good crystal structure data are available. Cluster analysis and neural network analysis will be employed to clarify inter-relationships in initial structural parameters. Results would be linked for an optimized single computational model. The hope is that the use of such a standard model for spectral data treatment will simplify understanding the wealth of new literature being produced on protein characterization. This project in experimental physical chemistry fulfills the program objective of advancing scientific knowledge by enabling leading researchers in the United States and Eastern Europe to combine complementary talents and pool research resources in areas of strong mutual interest and competence.