U.S.-Germany Collaborative Research in the Study of Alkyl Propargyl Biradicals

该奖项旨在支持洛克菲勒大学的William C. Agosta教授与德国汉堡大学有机化学研究所的Paul Margaretha教授在有机化学领域的持续合作。他们的共同研究重点是烷基丙炔双基化合物的三个化学问题。一个是自旋态对乙烯基碳中间体行为影响的机理研究。另一种是将他们最近发现的烯烃和3-炔基-2-环烯酮之间的（3+2）反应扩展到分子内体系。最后是探索2-炔基-2-环烯酮与烯烃的光化学环加成反应，包括分子间和分子内。两个实验室优势互补，各具特色。Agosta教授的兴趣是设计和合成特定的基质，以探索机制和寻找新的过程。他在洛克菲勒大学的小组由博士后组成。Margaretha教授在化学理论和自由基理论方面有特别的专长。他在汉堡的研究小组比Agosta教授的大得多，而且是由博士生组成的，这使得它能够更好地进行需要更多人力的研究。上述研究的长期目标是更好地了解烷基丙基双自由基形成的条件，确定这些双自由基转化为乙烯基羰基并从它们转化为稳定产物的机理。Agosta和Margaretha教授在1981年发现了烷基丙炔双基化合物。他们目前和建议的工作都涉及到这一领域的新化学或新的机制研究。

This award supports Professor William C. Agosta of the Rockefeller University for continued collaboration in organic chemistry with Professor Paul Margaretha of the Instiute for Organic Chemistry of the University of Hamburg, Germany. Their joint research focuses on three problems in the chemistry of alkyl propargyl biradicals. One is a mechanistic study of the influence of spin state on the behavior of vinyl carbene intermediates. Another is an extension of their recently discovered (3+2) reaction between alkenes and 3-alkynyl-2-cycloalkenones to intramolecular systems. The final is an exploration of the photochemical cycloaddition of 2-alkynyl-2-cycloalkenones with alkenes, both inter- and intra-molecularly. The two laboratories have complementary strengths and characteristics. Professor Agosta's interests are in the design and synthesis of particular substrates to probe mechanisms and to search for new processes. His small group at The Rockefeller University is composed of postdoctoral workers. Professor Margaretha has particular expertise in chemical theory and radical theory. His research group in Hamburg is much larger than Professor Agosta's and is composed of doctoral students, which makes it better able to carry out studies requiring greater manpower. The long term goals of the above research are to understand better the conditions under which alkyl propargyl biradicals are formed and to define the mechanism of conversion of these biradicals to vinyl carbenes and from them to stable products. Professors Agosta and Margaretha discovered alkyl propargyl biradicals in 1981. Their current and proposed work all involve either new chemistry or novel mechanistic studies in this general area.