Console Upgrade for 500MHz NMR Spectrometer

要求为500 MHz GE GN500核磁共振波谱仪提供一个新的控制台。该光谱仪将用于大分子结构的二维和三维核磁共振研究。将进行的结构研究包括研究(1)DNA三链，(2)DNA四链，(3)其他不寻常的DNA结构，包括含有B-Z连接的寡核苷酸，(4)药物-DNA复合体，(5)蛋白质-DNA复合体，(6)设计多肽-蛋白质复合体。新的控制台对于这些研究是必不可少的，以便能够实施新的三维核磁共振实验和需要成形脉冲的实验，并获得更高质量的二维核磁共振谱。新的控制台将取代已有6年历史的基于Nicolet 1280的GN500控制台，其中包含一台可以处理更复杂的脉冲序列和现代电子设备的计算机。

A new console for a 500 MHz GE GN500 NMR spectrometer is requested. The spectrometer will be used for two-and three- dimensional NMR studies of macromolecular structure. The structural studies to be carried out include investigations of the solution conformation of (1) DNA triplexes, (2) DNA quadruplexes, (3) other unusual DNA structures, including oligonucleotides containing B-Z junctions, (4) drug-DNA complexes, (5) protein-DNA complexes, (6) designed peptides- protein complexes. The new console is essential for these studies in order to be able to implement new three-dimensional NMR experiments and experiments which require shaped pulses and to obtain higher quality two-dimensional NMR spectra. The new console will replace a 6 year old Nicolet 1280-based GN500 console with a console that contains a computer that can handle more sophisticated pulse sequences and modern electronics.