Inclusion Chemistry of Flexible Hosts

该奖项由无机、生物无机和有机金属项目颁发给阿拉巴马大学的杰里·阿特伍德教授，将资助有关杯芳烃的嘉宾主持化学的继续研究。杯芳烃是一种灵活的大环（宿主），可以通过多种非共价相互作用将较小的分子（客体）结合在一起。重点将放在：1)与金属配合物作为一级和二级球体配体的相互作用，2)在水溶性的疏水腔中包裹水calixı4！芳烃，3)构象和配位较高（n=5-8） calixın！芳烃，4)进一步表征双层固体结构发现calizı4！芳烃磺酸盐及相关化合物。从这些研究中获得的关于主客相互作用性质的信息将对分离科学和生物化学产生影响。这项研究有望为分子间多种但高度特异性的非共价相互作用提供重要的基础信息。这种相互作用负责生物系统中酶对底物的识别，并允许在设计和合成合适的宿主时分离非常相似的分子混合物。

is award from the Inorganic, Bioinorganic and Organo- metallic Program to Professor Jerry Atwood of the University of Alabama will fund continued studies of guest-host chemistry involving calixarenes. Calixarenes are flexible, macrocycles (hosts) that can incorporate smaller molecules (guests) with multiple non-covalent interactions. Emphasis will be on: 1) interactions with metal complexes as primary and second sphere ligands, 2) inclusion of water in the hydrophobic cavity of water soluble calixı4!arenes, 3) conformation and complexation of higher (n=5-8) calixın!arenes, and 4) further characterization of bilayer solid state structures found for calizı4!arene sulfonates and related compounds. Information obtained from these studies on the nature of guest-host interactions will impact on separation science and biological chemistry. %%% This study is expected to provide important fundamental information about multiple, but highly specific, non-covalent interactions of molecules. Such interactions are responsible for recognition of substrates by enzymes in biological systems and allow for the separation of mixtures of very similar molecules when appropriate hosts can be designed and synthesized.