Site-specific protein functionalisation at diselenides via photocatalysis

该项目旨在开发一种新的光催化反应，用于蛋白质的按需功能化。该合成方法将解决该领域的一个主要技术空白，使人们能够有效地获得在特定位置具有定义修饰的蛋白质。该项目中产生的功能化蛋白质将有助于详细了解特定修饰如何影响几种重要蛋白质的结构和功能。该项目将在化学和生物学领域产生重要的新知识，并将促进国家和国际的跨学科合作。这项突破性的技术也有可能使澳大利亚的生物技术部门受益。

This project aims to develop a new photocatalytic reaction for the on demand functionalisation of proteins. The synthetic methodology will solve a major technological gap in the field by enabling efficient access to proteins with defined modifications at specific locations. Functionalised proteins generated in the project will underpin a detailed understanding of how specific modifications influence the structure and function of several important proteins. The project will generate significant new knowledge in the fields of chemistry and biology and will foster interdisciplinary collaboration, nationally and internationally. The breakthrough technology also has the potential to benefit Australia’s biotechnology sector.