New Polymers for Aqueous Two-Phase Extraction Systems

这个小型企业创新研究(SBIR)第一阶段项目是在分离科学的子领域的化学表征的一般领域。双水相萃取(ATPE)是一种温和的分离细胞、细胞器和生物产生的大分子(如酶)的方法。对于小规模的分离，ATPE是最经济的；然而，由于在提取系统中使用的聚合物的成本(例如葡聚糖)，成本变得不利于大规模的分离。在这个项目中，将合成经济、高效地提取蛋白质并具有其他有利于大范围分离的物理性质的新聚合物。

This Small Business Innovation Research (SBIR) Phase 1 project is in the general area of Chemical Characterization in the subfield of separation science. Aqueous two-phase extraction (ATPE) is a mild procedure for isolating cells, cellular organelles, and biologically produced macromolecules such as enzymes. For small scale separations, ATPE is most economical; however, due to the cost of polymers used in the extraction systems (e.g., dextran) costs become unfavorable for large scale separations. In this project new polymers will be synthesized that will be economical, extract proteins efficiently, and possess other physical properties favorable for large separations.