Complexation of charged polymers and nanoparticles at all aqueous interfaces for functional membrane formation

带电聚合物和纳米颗粒在所有水界面处络合以形成功能性膜

• 批准号: 1705891
• 负责人: Daeyeon Lee
• 金额: $ 34.03万
• 依托单位: University of Pennsylvania
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1705891&HistoricalAwards=false
• 关键词: Complexation; charged; polymers; nanoparticles; aqueous

CBET - 1705891PI: Lee, DaeyeonMicrocapsules are particles consisting of an interior core surrounded by a membrane. They are widely used in applications where the interior of the microcapsule contains an active ingredient that is released to the surroundings. Microcapsules are used in a variety of products, including food additives, drug carriers for timed release, healing agents, and pesticides. Microcapsules are especially effective when the permeability of the membrane is selective so that release rates of chemical components inside the microcapsule can be controlled and can be programmed to respond to changes in environmental conditions. This award will support experiments to synthesize and characterize microcapsules made with membranes composed of pairs of polyelectrolytes or a polyelectrolyte and nanoparticle. The membrane is formed by the spontaneous formation of a complex at the interface between two aqueous phases. The advantage of these microcapsules is that they are formulated completely in water-based systems, which makes them compatible with living cells and organisms. The details of the membrane formation process, the transport and mechanical properties of the membrane, and the encapsulation efficiency will be studied using a variety of techniques. The project will provide opportunities for graduate and undergraduate students to participate in the research. The team will also prepare a hands-on kit for students and teachers that demonstrates emulsion formation.This award will support an experimental program to understand the transport phenomena and thermodynamics that govern the formation and properties of functional membranes synthesized from polyelectrolytes and charged nanoparticles via interfacial complexation of polyelectrolyte-polyelectrolyte pairs or polyelectrolyte-nanoparticle pairs in aqueous two phase systems. The growth of the membranes and membrane dynamics will be investigated using (1) fluorescence microscopy of membranes formed with labeled components to identify their location as membranes form; (2) pendant drop-based observation and characterization of the elastic membranes, complemented by atomic force microscopy measurements;(3) fluorescence recovery after photobleaching-enabled measurements of polyelectrolyte mobility within the membranes; and (4) isothermal titration calorimetry to detect the thermal events during complexation. Membrane mechanical properties will be measured using micropipette aspiration and osmotic pressure-induced buckling methods. Results of the research will not only improve methods of forming microcapsules with functional membranes, but also will provide information that can be applied to the formation of functional membranes in other configurations.

CBET -1705891PI：Lee，DaeyeonMicrocapsules是由膜包围的内部核心组成的颗粒。 它们被广泛用于微胶囊内部包含释放到周围环境的活性成分的应用。 微胶囊用于多种产品，包括食品添加剂，用于定时释放的药物载体，治愈剂和农药。 当膜的渗透性有选择性时，微胶囊尤其有效，因此可以控制微胶囊内部化学成分的释放速率，并可以对其进行编程以应对环境条件的变化。该奖项将支持实验，以合成和表征由由成对聚电解质或聚电解质和聚电解质和纳米粒子组成的膜制成的微胶囊。 膜是通过两个水相之间的界面处的复合物自发形成形成的。 这些微胶囊的优点是它们完全在水基系统中配制，这使它们与活细胞和生物兼容。 膜形成过程的细节，膜的传输和机械性能以及封装效率将使用各种技术研究。 该项目将为研究生和本科生提供参与研究的机会。 The team will also prepare a hands-on kit for students and teachers that demonstrates emulsion formation.This award will support an experimental program to understand the transport phenomena and thermodynamics that govern the formation and properties of functional membranes synthesized from polyelectrolytes and charged nanoparticles via interfacial complexation of polyelectrolyte-polyelectrolyte pairs or polyelectrolyte-nanoparticle pairs在水性两个相系统中。将使用（1）用标记成分形成的膜的荧光显微镜研究膜和膜动力学的生长，以识别其位置为膜形式； （2）基于吊坠的观察和弹性膜的表征，与原子力显微镜测量相辅相成；（3）在膜内多电解质迁移率的光漂白后荧光恢复； （4）等温滴定量热法以检测络合过程中的热事件。膜机械性能将使用微孔抽吸和渗透压诱导的屈曲方法测量。 研究结果不仅将改善用功能膜形成微胶囊的方法，而且还将提供可以应用于其他配置中功能膜的形成的信息。

项目成果

Scalable Synthesis of Janus Particles with High Naturality

• DOI: 10.1021/acssuschemeng.0c04929
• 发表时间: 2020-11
• 期刊: ACS Sustainable Chemistry & Engineering
• 影响因子: 8.4
• 作者: Yang Lan;Yang Lan;Jingyu Wu;Syung Hun Han;S. Yadavali;D. Issadore;K. Stebe;Daeyeon Lee

All-Aqueous Assemblies via Interfacial Complexation: Toward Artificial Cell and Microniche Development

• DOI: 10.1021/acs.langmuir.7b02237
• 发表时间: 2017-10-03
• 期刊: LANGMUIR
• 影响因子: 3.9
• 作者: Hann, Sarah D.;Stebe, Kathleen J.;Lee, Daeyeon
• 通讯作者: Lee, Daeyeon

Effect of Confinement on Solvent-Driven Infiltration of the Polymer into Nanoparticle Packings

• DOI: 10.1021/acs.macromol.0c01057
• 发表时间: 2020-07
• 期刊: Macromolecules
• 影响因子: 5.5
• 作者: N. Manohar;K. Stebe;Daeyeon Lee

Janus Particles with Varying Configurations for Emulsion Stabilization

• DOI: 10.1021/acs.iecr.9b02697
• 发表时间: 2019-07
• 期刊: Industrial & Engineering Chemistry Research
• 影响因子: 4.2
• 作者: Yang Lan;Je Choi;Haoyang Li;Yankai Jia;Renjing Huang;K. Stebe;Daeyeon Lee