Symposium: Comparative Gastrointestinal Endocrinology: Integration of Function

胃肠道是一个动态的、化学感官的内分泌器官，集摄食行为、消化、吸收和同化于一体。这项提议要求支持一次为期一天的研讨会，以研究荷尔蒙是如何调节这种整合的。题为“比较胃肠内分泌学：功能整合”的研讨会将是1992年12月在不列颠哥伦比亚省温哥华举行的美国动物学家协会年会的一部分。这次研讨会有三个目标。首先，十位演讲者将研究他们研究的不同过程如何有助于整个消化系统的调节。其次，荷尔蒙控制肠道功能的例子将来自从哺乳动物到昆虫的各种动物群体。第三，研讨会将强调激素作用，而不是肠道激素化学。结果应该是：1)对功能已知的调节因子的综合作用进行评估；2)确定具有已知结构但未知功能的“孤立”化学介体的作用的策略；3)了解在远离肠道的部位释放的肠肽和激素之间的相互作用；以及4)评估非哺乳动物脊椎动物和无脊椎动物的最佳生物模型，以简化规律性复杂性和构建内分泌调节的系统发育图。

The gastrointestinal tract is a dynamic, chemosensory endocrine organ that integrates feeding behavior, digestion, absorption, and assimilation. This proposal requests support for a one day symposium to examine how that integration is mediated by hormones. Entitled "Comparative Gastrointestinal Endocrinology: Integration of Function," the symposium will be part of the American Society for Zoologists annual meeting held in Vancouver, B.C. in December 1992. The symposium has three objectives. First, the ten speakers will examine how the separate processes they investigate contribute to the regulation of the whole digestive system. Second, examples of the hormonal control of gut function will come from animal groups ranging from mammals to insects. Third, the symposium will emphasize hormone actions, rather than gut hormone chemistry. The outcome should lead to: 1) an evaluation of the integrative roles of regulatory factors for which functions are known; 2) strategies for determining the actions of "orphaned" chemical mediators, having known structures but unknown functions; 3) knowledge of interactions between gut peptides and hormones released at sites remote from the gut; and 4) an assessment of optimal biological models in nonmammalian vertebrates and invertebrates, for simplifying regularity complexity and for constructing the phylogeny of endocrine regulation.