Population Genetics of DNA Polymorphisms

遗传学记录是研究人类短期遗传变化的重要资源。这项研究的主要目的是利用芬兰奥兰德群岛的档案记录进行这两项分析。首先，过去250年有很好的档案记录，便于进行长期的人口研究以及构建多代谱系。其次，这个群体有几种遗传病的高发频率，这些疾病在其他群体中非常罕见。研究人员感兴趣的是确定导致这些疾病频率的进化力量。该项目的最初目标是完成Aland档案记录的计算机录入，以便将其用于对所有人口的家谱进行计算机化构建。这将允许分析近亲交配水平、非随机交配、遗传隔离程度，以及个别祖先创始人可能在多大程度上为当前一代人做出不成比例的遗传贡献。这些研究将具有进化意义，它们将有助于解释为什么奥兰岛人口有一些遗传病的高发病率。

Geneological records are an important resource for the study of human genetic change over short periods of time. The primary objective of this research is to utilize the archival records of the Aland Islands, Finland, for such two such analyses. First, excellent archival records are available for the past 250 years, facilitating long-term demographic studies as well as the construction of multigenerational pedigrees. Second, this population has high frequencies of several genetic diseases that are very rare in other populations. The investigators are interested in determining the evolutionary forces responsible for these disease frequencies. The initial goal of this project is to complete the computer entry of archival records from Aland so that they can be used in a computerized construction of pedigrees for the entire population. This will allow the analysis of inbreeding levels, nonrandom mating, the degree of genetic isolation, and the extent to which individual ancestral founders may have made disproportionate genetic contributions to the current generation. These studies will have evolutionary significance, and they will help to explain why the Aland Islands population has a high incidence of some genetic diseases.