New Avenues for the Intramolecular Diyl Trapping Reaction

这项研究的重点是双重的。在第一个领域，将探索使用分子内二基捕获来制备紫杉醇相关化合物。在第二个领域，使用1，3-二基作为伙伴？4+3！与1，3-二烯的环加成反应，环丁烯酮的环加成反应，然后裂解的分子内反应，以及直接的7-endo，trig环化反应将被用于形成包含七元环或八元环的化合物。有了这个续约奖，合成有机计划正在支持加州大学圣巴巴拉分校化学系的R.Daniel Little博士的研究。利特尔教授将专注于开发双自由基(二基)捕获策略，用于合成紫杉醇相关系统，以及制备含有七元或八元环的碳化合物。

The focus of this research is two-fold. In the first area, the use of intramolecular diyl trapping for the preparation of taxol-related compounds will be explored. In the second area, the use of 1,3-diyls as partners in ?4+3! cycloadditions with 1,3-dienes, intramolecular reactions involving cycloaddition to cyclobutenones followed by fragmentation, and direct 7-endo,trig cyclization reactions will be used to form compounds containing either seven or eight-membered rings. %%% With this Renewal award, the Synthetic Organic Program is supporting the research of Dr. R. Daniel Little of the Department of Chemistry at the University of California, Santa Barbara. Professor Little will focus his work on the development of diradical (diyl) trapping strategies for the synthesis of taxol-related systems and for the preparation of carbon compounds containing seven or eight-membered rings.