The dynamic interplay between the matrix and cell fate in developing heart

发育中的心脏畸形可能会导致灾难性的缺陷和胚胎丧失。这些瓣膜在血流调节中起着至关重要的作用，并且是由早期开发的分层基质制成的。该项目旨在确定早期瓣膜细胞的细胞命运如何建立分层的基质，进而通过利用多组学方法确定独特的细胞群体并整合基质破坏期间转录和蛋白质的变化，从而影响细胞命运。该项目预计将产生有关基质结构如何影响瓣膜中细胞命运的基础知识，并将促进澳大利亚在发育生物学方面的知识库和研究能力。

Malformations in the developing heart can lead to catastrophic defects and embryonic loss. The valves play a critical role in blood flow regulation and are made of a stratified matrix that is laid down early in development. This project aims to determine how the cellular fate of the early valve cells establish the layered matrix and in turn how the matrix can influence cell fate by utilising a multi-omics approach to identify unique cell populations and integrate transcriptional and protein changes during matrix disruption. This project expects to generate fundamental knowledge on how matrix structure can influence cell fate in the valves and will advance Australia's knowledge base and research capabilities in developmental biology.