Studies of Receptor-Based Chemical Sensors

这个项目是在一般地区的分析和表面 化学和化学传感器领域。 期间 在这三年的持续资助下，Bright教授和 他的学生们将在以前研究成果的基础上 在NSF资助CHE-8921517下支持，并采用激发态 荧光衰减动力学研究固定化活性 抗体片段及其与可溶性抗原的相互作用。 这项研究的总体目标是提高我们的 了解生物和合成化学识别 固定在界面上的元素（受体）。 %%% 这项研究将产生关于 表面固定受体的热力学和动力学 （人工和生物化学），从而提供有价值的见解 指导开发适合化学品的接口， 传感在复杂的环境中，并使合理的设计， 各种技术上重要的基于受体的传感 装置.

This project is in the general area of analytical and surface chemistry and in the subfield of chemical sensors. During the tenure of this three-year continuing grant, Professor Bright and his students will build upon results derived from previous studies supported under NSF grant CHE-8921517 and employ excited state fluorescence decay kinetics to study the immobilization of active antibody fragments and their interaction with a soluble antigen. The overall goal of this research is directed toward improving our understanding of biological and synthetic chemical recognition elements (receptors) immobilized at an interface. %%% This research will yield fundamental information on the thermodynamics and dynamics of surface-immobilized receptors (artificial and biochemical) thereby providing valuable insights to guide the development of interfaces suitable for chemical sensing in complex milieu and enable the rational design of a variety of technologically important receptor-based sensing devices.