U.S.-Chile Cooperative Research: Light-Activated Ion Channels in Visual Receptors

9301719 O’day美国-智利奖将支持俄勒冈大学尤金分校的Peter O’day博士与智利大学的Juan Bacigalupo博士合作进行一项研究。研究人员将研究果蝇光感受器中光激活通道的门控，并验证有不止一种生化途径参与转导的概念。光转化为电信号的机制尚不清楚。本研究的总体目标是增强我们对果蝇光感受器的视觉转导以及转导通路的激活和调节的理解。由于果蝇与其他生物系统的相似之处，也因为它可以被基因操纵和电生理学研究，因此使用果蝇作为模型系统将为一般细胞信号传导中的类似问题提供重要线索。＊＊＊

9301719 O'Day This U.S.-Chile award will support Dr. Peter O'Day, of the University of Oregon, Eugene, in a research collaboration with Dr. Juan Bacigalupo, of the University of Chile. The researchers will investigate the gating of light-activated channels in Drosophila photoreceptors and test the concept that there is more than one biochemical pathway involved in transduction. The mechanism by which light is transduced to an electrical signal is still unclear. The overall goal of the research is to enhance our understanding of visual transduction in Drosophila photoreceptors and the activation and modulation of transduction pathways. Because of its similarities to other biological systems, and because it can be genetically manipulated as well as electro- physiologically studied, the use of Drosophila as a model system will provide important clues to similar issues in cellular signalling in general. ***