Molecular Cloning of Patterning Genes in the Slime Mold Polysphondylium Pallidum

9304849 Cox苍白草（Polysphondylium pallidum）在其生命周期中形成独特的空间格局。其中一种模式，孢子臂的放射状排列，产生于发育中的生物体底部的球状细胞群。放射状图案形成球形图案的出现是一个真正的对称破坏事件，考克斯博士通过检查相关基因的结构和功能来研究这一事件。通过基因捕获方法分离出编码模式元件的基因，并用于研究它们在发育过程中转录的时间和调控。本研究的长期目标是了解一个简单系统的形态发生，以联系细胞间相互作用的各种贡献，扩散化学信号及其受体的作用，以及细胞间粘附和细胞运动的贡献。＊＊＊

9304849 Cox Polysphondylium pallidum forms distinctive spatial patterns during its life cycle. One of these patterns, the radial arrangement of spore bearing arms, arises from a spheroidal mass of cells at the base of the developing organism. The emergence of the radial pattern form a spheroidal one is a true symmetry breaking event which Dr. Cox studies by examining the structure and function of the genes involved. The genes coding for patterning elements are isolated by a gene trapping method and used to study the timing and regulation of their transcripts during development. The long range goal of this research is an understanding of morphogenesis in a simple system with a view to relating the various contributions made by cell-cell interactions, the roles played by diffusible chemical signals and their receptors, and the contributions of intercellular adhesion and cell movement. ***