Proton Transfers and Nucleophilic Reactions in Organic and Organometallic Systems

有机动力学计划的这笔赠款支持以下工作： 位于圣克鲁斯的加州大学的伯纳斯科尼教授 研究质子转移的异步过渡态， 亲核加成和取代反应， 非完美同步原理的具体目标 （a）分离极化率和共振效应， 硫和磷取代阴离子，（B）研究质子 通过实验和理论从碳到碳的转移，以及（c） 研究金属取代对质子的影响， 转移障碍以及更广泛的领域， Fischer C=M双键的亲核加成 卡宾配合物。 %%% 在这个项目中，伯纳斯科尼教授将运用他的经验， 理论，非完美同步原理，研究 异步质子转移反应和Fischer加成 卡宾配合物。他的物理有机应用 普遍存在的金属卡宾化学的方法学将 填补了一个重要的空白。

This grant from the Organic Dynamics Program supports the work of Professor Bernasconi at the University of California, Santa Cruz to study asynchronous transition states of proton transfer and nucleophilic addition and substitution reactions using the principle of nonperfect synchronization. The specific targets are: (a) to separate the polarizability and resonance effects in sulfur and phosphorus substituted anions, (b) to study proton transfer from carbon to carbon by experiment and theory, and (c) to study the influence of metallic substitution on proton transfer barriers as well as the more general area of nucleophilic additions to the C=M double bonds of Fischer carbene complexes. %%% In this project Professor Bernasconi will employ his empirical theory, the principle of nonperfect synchronization, to study asynchronous proton transfer reactions and additions to Fischer carbene complexes. The application of his physical organic methodology to the ubiquitous chemistry of metal carbenes will fill an important void.