Mechanisms and targeting of repair deficient cancers with G-quadruplex small molecule ligands
Mechanisms and targeting of repair deficient cancers with G-quadruplex small molecule ligands
批准号:
478057
负责人:
Aparicio Samuel J
金额:
$76.35万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2023
资助国家:
加拿大
项目状态:
未结题
起止时间:
2023-03-01 至 2028-03-01
关键词:
中文摘要
三阴性乳腺癌(TNBC)约占早期乳腺癌的15%,其中75%的TNBC预后不良。我们的目标是通过开发治疗方法来降低这些和其他基因组不稳定癌症的死亡率和发病率
英文摘要
Triple negative breast cancer (TNBC) accounts for ~15% of early breast cancers, and 75% of TNBCs have poor prognoses. Our objective is to lower mortality and morbidity from these and other genomically unstable cancers, by developing therapeutic approaches
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会议论文
Decoding the impact of single cell mutational processes in triple negative breast cancer and high grade serous ovarian cancer
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批准号:477662
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项目类别:Operating Grants
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资助金额:$75.79万
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财政年份:2023
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负责人:Aparicio Samuel J
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依托单位:
Decoding the impact of single cell mutational processes in triple negative breast cancer and high grade serous ovarian cancer.
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批准号:477245
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项目类别:Operating Grants
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资助金额:$7.29万
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财政年份:2022
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负责人:Aparicio Samuel J
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依托单位:
Canada Research Chair - Tier 1
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批准号:459667
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项目类别:
-
资助金额:$101.99万
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财政年份:2021
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负责人:Aparicio Samuel J
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依托单位:
Targeting the dynamics and genomics of clonal evolution in cancer patients
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批准号:333653
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项目类别:Operating Grants
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资助金额:$206.42万
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财政年份:2015
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负责人:Aparicio Samuel J
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依托单位:
Canada Research Chair Tier 1
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批准号:332843
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项目类别:
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资助金额:$101.99万
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财政年份:2014
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负责人:Aparicio Samuel J
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依托单位:
Linking clonal genomes to tumour evolution and therapeutics
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批准号:266702
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项目类别:Operating Grants
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资助金额:$75.8万
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财政年份:2012
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负责人:Aparicio Samuel J
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依托单位:
PP2a protein serine/threonine phosphatase mutations in cancer: functional consequences and clinical relevance
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批准号:238781
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项目类别:Operating Grants
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资助金额:$42.9万
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财政年份:2011
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负责人:Aparicio Samuel J
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依托单位:
CANADA RESEARCH CHAIRHOLDER / TITULAIRE DE CHAIRE DE RECHERCHE DU CANADA
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批准号:204208
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项目类别:
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资助金额:$36.43万
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财政年份:2009
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负责人:Aparicio Samuel J
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依托单位:
Improving computational inference of single nucleotide variants from next generation sequencing of cancer genomes.
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批准号:182345
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项目类别:Operating Grants
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资助金额:$7.22万
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财政年份:2009
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负责人:Aparicio Samuel J
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依托单位:
海外基金