Decode Neuro-Mechanobiology:mechanosensitive ion channels in proprioception

人体上密密麻麻地覆盖着许多机械感觉神经元，它们为我们提供触觉和疼痛的感觉。然而，分子力传感器的识别能力仍然很差。这个项目旨在确定机械敏感离子通道在感知和响应各种机械刺激方面的基本作用，以及它们的反应如何编码机械提示。最终目标是对本体感觉和运动感觉有一个全新的理解。该项目产生的新的多模式方法有望发展成为国家神经机械生物学设施，未来的研究可能会为未来的神经工程行业带来新的仿生传感器设计和脑机接口的灵感。

Human bodies are densely covered with numerous mechanosensory neurons that provide us with the sense of touch and pain. However, the molecular force sensors remain poorly identified. This project aims at defining the fundamental roles of mechanosensitive ion channels to sense and respond to various mechanical stimuli, and how their responses may encode mechanical cues.The ultimate goal is to provide a fundamentally new understanding of proprioception and motion sensing. The new multimodality approach generated in this project is expected to evolve as a national facility for neuro-mechanobiology, and future research may lead to the inspiration of novel bionic sensor design and brain-computer interface for future neuroengineering industry.