A New Synthetic Method For the Preparation of Phosphonate Analogs of Bio-active Organophosphates

9312231麦克卢尔这项研究的重点是开发五价有机膦化学作为生产含膦化合物的一种新的合成方法。氧磷烯将与各种亲电试剂缩合，得到高取代度的膦酸盐。反过来，这些磷酸盐将为生产肌醇磷酸盐、神经鞘蛋白、碳水化合物和C-核苷类似物提供中间体。有了这个奖项，合成有机计划支持特拉华大学化学系的辛西娅·K·麦克卢尔博士的研究。麦克卢尔教授将把她的工作重点放在合成简单的具有生物活性的磷酸盐类似物上。目标化合物作为抗代谢物和酶活性位点探针具有潜在的应用价值。***

9312231 McClure The focus of this research is the development of pentavalent organophospholene chemistry as a new synthetic method for the production of phosphonate-containing compounds. The oxophospholenes will be condensed with a variety of electrophiles to give highly substituted phosphonates. The phosphonates, in turn, will provide intermediates for the production of inositol phosphates, sphingomyelins, carbohydrates and C-nucleoside analogs. %%% With this award, the Synthetic Organic Program is supporting the research of Dr. Cynthia K. McClure of the Department of Chemistry at the University of Delaware. Professor McClure will focus her work on the synthesis of simple phosphonate analogs of biologically active phosphates. The target compounds are of potential interest as antimetabolites and enzyme active- site probes. ***