U.S.-Korea Cooperative Research on Physical and Synthetic Studies of Organometallic Electrophiles

9312709 Sweigart该奖项将资助布朗大学化学系Dwight a . Sweigart博士与韩国首尔国立大学化学系Young K. Chung博士进行为期24个月的合作研究项目，涉及有机金属亲电试剂的物理和合成研究。该项目将包括有机金属合成和电化学。合成研究将涉及使用锰(1)将芳烃转化为双官能化的光学纯环己二烯；(2)产生吲哚、类固醇和与维生素D和k相关的天然产物的新官能化衍生物。研究的电化学部分旨在研究17电子和19电子有机金属自由基在配体取代和其他转化方面的反应性。这项研究如果成功，将会引起许多化学家的极大兴趣，包括那些关注天然产物和药物领域有机合成的化学家。PI和他的韩国合作者是该研究领域备受尊敬的化学家。他们的专业知识是互补的。钟博士的团队在广泛的合成程序方面是专家，并将负责大约三分之二的合成工作。PI的小组将完成大约三分之一的合成工作和大部分的电化学和计算机工作。研究人员将得到3名美国研究生和几名韩国研究生的协助。该项目与美国-韩国合作科学计划的目标相关，该计划旨在通过交流科学信息、思想、技能和技术以及通过在互惠问题上的合作来提高美国和韩国科学家和工程师之间的合作水平。韩国参与该项目得到了韩国科学工程财团（KOSEF）的支持。该项目在美国国家科学基金（NSF）资助下为PI的研究增加了一个国际合作的维度。切——8821588。＊＊＊

9312709 Sweigart This award provides funds to permit Dr. Dwight A. Sweigart, Department of Chemistry, Brown University, to pursue with Dr. Young K. Chung, Department of Chemistry, Seoul National University, Korea, for 24 months, a program of cooperative research involving physical and synthetic studies of organometallic electrophiles. The project will include both organometallic synthesis and electrochemistry. The synthetic studies will involve the use of manganese to (1) convert arenes to difunctionalized optically pure cyclohexadienes and (2) produce new functionalized derivatives of indoles, steroids, and natural products related to vitamins D and K. The electrochemical part of the research is designed to study the reactivity of 17- and 19-electron organometallic radicals with respect to ligand substitution and other transformations. The proposed research, if successful, will be of significant interest to a range of chemists, including those concerned with organic synthesis in the natural products and drug fields. The PI and his Korean collaborator are highly respected chemists in the fields of this research. Their expertise is complementary. Dr. Chung's group is expert in a wide range of synthetic procedures and will be responsible for perhaps two thirds of the synthetic work. The PI's group will do perhaps one third of the synthetic work and most of the electrochemical and computer work. The collaborators will be assisted by three U.S. graduate students supported by this grant and several Korean graduate students. This project is relevant to the objectives of the U.S.- Korea Cooperative Science Program which seeks to increase the level of cooperation between U.S. and Korean scientists and engineers through the exchange of scientific information, ideas, skills, and techniques and through collaboration on problems of mutual benefit. Korean participation in the project is supported by the Korea Science and Engineering Foundation (KOSEF). This project adds an international cooperative dimension to the PI's research under NSF Grant No. CHE-8821588. ***