Molecular Processes in Non-Newtonian Fluids

9315906 Rotello该奖项是Rotello博士化学博士后研究奖学金的启动资助增量。研究的重点将放在非牛顿流体中的分子过程。溶液组织将用于模拟由蛋白质和核酸结构创建的有序但动态的环境。在这些溶液中形成的动态口袋将提供酶催化中存在的许多特征，如局部反应物浓度和构象“压力”。这些影响的大小可以通过核磁共振监测，并通过修改物理条件（如自旋速率和样管尺寸）来改变。分子识别和催化也将在非牛顿溶液中进行研究。非牛顿流体在自然界广泛存在，包括血液、球状蛋白内部和原生质。这些典型的水性聚合物溶液粘度随外加应力的变化而变化。本研究将探讨非牛顿条件下生物和合成聚合物的基本性质。＊＊＊

9315906 Rotello This award is the starter grant increment of Dr. Rotello's Postdoctoral Research Fellowship in Chemistry award. The focus of the research will be on molecular processes in non-Newtonian fluids. Solution organization will be used to model the ordered, yet dynamical environment created by protein and nucleic acid structures. The dynamic pockets formed in these solutions will provide many of the features present in enzymatic catalysis such as local concentration of reactants and conformational "pressure". The magnitude of these effects can be monitored by NMR and varied by modifying physical conditions such as spin rate and sample tube size. Molecular recognition and catalysis will also be studied in non-Newtonian solutions. %%% Non-Newtonian fluids are widespread in nature including blood, the interior of globular proteins and protoplasm. These typically aqueous polymer solutions vary their viscosity as a function of the applied stress. This research will address the fundamental nature of biological and synthetic polymers under non-Newtonian conditions. ***