Development of Diiron Bridging Acyl Complexes in Organic Synthesis

9316821本研究的重点是二铁桥联酰基化合物在有机合成中的应用。这些二铁络合物有五个具体的方面需要研究。第一个是光学纯手性配合物的合成和拆分。第二是研究金属从初始产物中的还原裂解，这将使分子中的金属部分得以回收利用。第三是研究二铁酰基络合物氧化生成硫代酯的实用性。第四，考察了这些络合物作为不对称Michael受体的作用。五是对脱羰基产物的化学进行了研究。有了这个奖项，合成有机计划将支持华盛顿大学化学系的Scott R.Gilbertson博士的研究。吉尔伯森教授将专注于合成方法学领域的工作，通过研究双铁有机金属络合物的使用来完成一些新的合成转化。***

9316821 The focus of this research is the use diiron bridging acyl complexes in organic synthesis. There are five specific aspects of these diiron complexes that will be studied. The first is the synthesis and resolution, if necessary, of optically pure chiral complexes. Second is the investigation of reductive cleavage of the metal from the inital products which will allow the metal portion of the molecule to be recycled. Third is the study of the utlity of the formation of thioesters from the oxidation of the diiron acyl complex. Fourth is the examination of these complexes as asymmetric Michael acceptors. Fifth is the investigation of the chemistry of the decarbonylation product. %%% With this award, the Synthetic Organic Program is supporting the research of Dr. Scott R. Gilbertson of the Department of Chemistry at Washington University. Professor Gilbertson will focus his work in the area of synthetic methodology by studying the use of diiron organometallic complexes to accomplish a number of novel synthetic transformations. ***