Dynamic, Structural and Chemical Studies of Carbanionic Species

这项来自有机动力学项目的资助支持俄亥俄州立大学Gideon Fraenkel教授的工作，通过各种核磁共振技术，使用13-C、6-Li、NOE程序和线型分析，研究溶剂化和非溶剂化团簇和有机锂化合物离子对的结构和动力学方面。研究的具体目标是(a)未溶剂化（RLi）n簇，(b) RLi物种之间的相互作用(c)二锂化合物(d)离子与离子对重定向的缓慢动力学，(e)液晶介质中离子对的映射，(f)高烷基取代的有机锂试剂，以及(g)烯丙基有机金属中的旋转机制。在这个项目中，Gideon Fraenkel教授将探索与金属锂反应产生的有机化合物的独特行为。如果溶剂性质改变，这些有机锂物质倾向于在溶液中聚集或离解。由于有机锂试剂经常用于生产有价值的药物和自然存在的化合物，该项目将增强我们对锂物种如何反应的基本理解，其结果将有助于建立有机锂试剂的实用用途。＊＊＊

9317298 Fraenkel This grant from the Organic Dynamics program supports the work of Professor Gideon Fraenkel at The Ohio State University to study structural and dynamic aspects of solvated and unsolvated clusters and ion-pairs of organolithium compounds by a variety of NMR techniques using 13-C, 6-Li, NOE procedures, and line shape analysis. The specific targets for study are (a) unsolvated (RLi)n clusters, (b) interactions between RLi species (c) dilithium compounds (d) slow dynamics of reorientation of ions with ion-pairs, (e) mapping of ion-pairs in liquid crystal media, (f) highly alkyl substituted organo lithium reagents, and (g) mechanisms of rotation in allyl organometallics. %%% In this project Professor Gideon Fraenkel will explore the unique behavior of organic compounds derived from a reaction with the metal lithium. These organolithium substances tend to aggregate or dissociate in solution if the solvent character is changed. Because organolithium reagents are often used to produce valuable pharmaceuticals and naturally occuring compounds, this project will enhance our fundamental understanding of how lithium species react and the results will help establish utilitarian uses of organolithium reagents. ***