Gel Release Technology: Simulation with Experimental Verification

9361271 Sachs该项目的目标是改进聚合物凝胶在农业、制药、化工生产和净化行业应用中的性能预测和优化。这些改进将通过对聚合物凝胶中传输、流动和膨胀的进一步了解来实现：(1)阐明聚合物凝胶行为的基本物理现象；(2)用数学模型对这些现象进行量化；(3)开发了一个经过实验验证的软件工具来实现这些模型。该软件可以显著加快凝胶基技术的设计和优化。在第一阶段，基于原型模型的数值计算将预测凝胶膨胀和应力、电荷密度、溶质浓度以及溶质和溶剂通量。该模型将通过将其预测结果与蓝葡聚糖释放实验进行比较来验证。＊＊＊

9361271 Sachs The goal of this project is to improve the prediction and optimization of the performance of polymer gels in applications in the agricultural, pharmaceutical, and chemical production and purification industries. These improvements will be brought about by increased understanding of transport, flow, and swelling in polymer gels through: (1) elucidation of the physical phenomena fundamental to their behavior; (2) quantification of these phenomena in a mathematical model; and (3) development of an experimentally verified software tool implementing these models. Design and optimization of gel-based technologies could be significantly accelerated by this software. In Phase I, numerical computations based on a prototype model will predict gel swelling and stresses, charge density, solute concentrations, and solute and solvent fluxes. The model will be validated by comparing its predictions with an experiment on release of blue dextrans. ***