U.S.-France Cooperative Research: Modeling 40 Hz Cortical Oscillations

这个为期三年的奖项将支持美国匹兹堡大学的王晓静和法国巴黎综合理工学院的大卫·汉塞尔在生物物理建模方面的美法合作研究。他们的研究目标是对神经元和神经系统的40赫兹振荡进行生物物理建模。他们会讲到：节奏发生；网络机制下的同步性和大变异性；以及40赫兹振荡的间歇性。哺乳动物大脑在30至50赫兹振荡频率下的节律性活动已被证明与注意力集中的增强相一致，并可能在感知和信息处理中发挥重要的功能作用。通过结合研究人员的独特能力，建议合作重点关注这些生理和认知问题。这位美国研究者为这次合作带来了生物物理建模方面的专业知识。这是由法国调查员在大型神经网络动力学的专业知识补充。他们的共同努力将推进我们对神经元合作节律的生理和生物物理机制及其在哺乳动物大脑活动组织中的作用的认识。

This three-year award will support U.S.-France cooperative research in biophysical modeling between Xiao-Jing Wang of the University of Pittsburgh and David Hansel of the Ecole Polytechnique, Paliseau, France. The objective of their research is to undertake biophysical modeling of 40 Hz oscillations in neurons and neural systems. They will address: rhythmogenesis; network mechanisms underlying synchronization and large variability; and the intermittent nature of 40 Hz oscillations. Rhythmic activity in mammalian brains at the 30 to 50 Hz oscillation rate has been shown to coincide with increased focal attention and may have important functional roles in perception and information processing. The proposed collaboration focuses on these physiological and cognitive issues by combining unique abilities of the investigators. The U.S. investigator brings to this collaboration expertise in biophysical modeling. This is complemented by the French investigator's expertise in the dynamics of large neural networks. Their joint effort will advance our knowledge of the physiological and biophysical mechanisms underlying neuronal cooperative rhythmically and its role in the organization of mammalian brain activity.