Computer Simulation of Sleep Slow Oscillations in the Thalamic Circuitry: Role of Synaptic Inhibition

9409202王，在不同的行为中，特别是在睡眠的不同阶段，可以从大脑表面记录到几种不同类型的节奏振荡。大约7-14赫兹的振荡发生在睡眠的早期阶段，而0.5-5赫兹的较慢的振荡发生在睡眠的后期阶段。已知7-14赫兹的振荡来自丘脑，有证据表明较慢的振荡也可能是丘脑的振荡。然而，目前还不清楚丘脑神经元是如何产生这些振荡的。在这项由一位年轻物理学家进行的研究中，将对这些节奏振荡进行数学和计算模型研究。本课程将研究丘脑和皮质之间的连接作用，以及个别丘脑神经细胞的特性在产生这些振荡中的作用。这些理论研究应该提供对这些振荡的起源的洞察，以及那些在感觉感知过程中发生在大脑中的振荡，以及那些与其他行为相关的振荡。

9409202 Wang Several different types of rhythmic oscillations can be recorded from the surface of the brain during different behaviors, particularly during different stages of sleep. Oscillations of about 7-14 Hz occur during early stages of sleep and slower oscillations of 0.5-5 Hz occur during later stages of sleep. It is known that the 7-14 Hz oscillations arises from the thalamus and there is some evidence that the slower oscillation may also be a thalamic oscillation. However, it is not known exactly how the neurons of the thalamus produce these oscillations. In this study from a young physicist, mathematical and computational modelling studies of these rhythmic oscillations will be carried out. The role of connections between the thalamus and cortex and the role of properties of individual thalamic nerve cells in the production of these oscillations will be examined. These theoretical studies should provide insights into the original of these oscillations as well as those that occur in the brain during sensory perception and those associated with other behaviors.