Computer Simulation of Sleep Slow Oscillations in the Thalamic Circuitry: Role of Synaptic Inhibition

在不同的行为中，特别是在睡眠的不同阶段，可以从大脑表面记录到几种不同类型的节律振荡。大约7-14赫兹的振荡发生在睡眠的早期阶段，0.5-5赫兹的较慢振荡发生在睡眠的后期阶段。众所周知，7- 14hz的振荡源于丘脑，有证据表明，较慢的振荡也可能是丘脑振荡。然而，尚不清楚丘脑的神经元是如何产生这些振荡的。在这项年轻物理学家的研究中，将对这些有节奏的振荡进行数学和计算建模研究。丘脑和皮层之间的连接的作用和单个丘脑神经细胞的特性在这些振荡的产生中的作用将被检查。这些理论研究应该为这些振荡的起源以及在感觉知觉过程中发生在大脑中的振荡以及与其他行为相关的振荡提供见解。

9409202 Wang Several different types of rhythmic oscillations can be recorded from the surface of the brain during different behaviors, particularly during different stages of sleep. Oscillations of about 7-14 Hz occur during early stages of sleep and slower oscillations of 0.5-5 Hz occur during later stages of sleep. It is known that the 7-14 Hz oscillations arises from the thalamus and there is some evidence that the slower oscillation may also be a thalamic oscillation. However, it is not known exactly how the neurons of the thalamus produce these oscillations. In this study from a young physicist, mathematical and computational modelling studies of these rhythmic oscillations will be carried out. The role of connections between the thalamus and cortex and the role of properties of individual thalamic nerve cells in the production of these oscillations will be examined. These theoretical studies should provide insights into the original of these oscillations as well as those that occur in the brain during sensory perception and those associated with other behaviors.