Computer Simulation of Sleep Slow Oscillations in the Thalamic Circuitry: Role of Synaptic Inhibition

丘脑回路睡眠慢振荡的计算机模拟：突触抑制的作用

• 批准号: 9409202
• 负责人: Xiao-Jing Wang
• 金额: $ 18.81万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-08-15 至 1996-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9409202&HistoricalAwards=false
• 关键词: Computer; Simulation; Sleep; Slow; Oscillations

9409202 Wang Several different types of rhythmic oscillations can be recorded from the surface of the brain during different behaviors, particularly during different stages of sleep. Oscillations of about 7-14 Hz occur during early stages of sleep and slower oscillations of 0.5-5 Hz occur during later stages of sleep. It is known that the 7-14 Hz oscillations arises from the thalamus and there is some evidence that the slower oscillation may also be a thalamic oscillation. However, it is not known exactly how the neurons of the thalamus produce these oscillations. In this study from a young physicist, mathematical and computational modelling studies of these rhythmic oscillations will be carried out. The role of connections between the thalamus and cortex and the role of properties of individual thalamic nerve cells in the production of these oscillations will be examined. These theoretical studies should provide insights into the original of these oscillations as well as those that occur in the brain during sensory perception and those associated with other behaviors.

小行星9409202 在不同的行为过程中，特别是在睡眠的不同阶段，可以从大脑表面记录到几种不同类型的节律振荡。 大约7-14 Hz的振荡发生在睡眠的早期阶段，0.5-5 Hz的较慢振荡发生在睡眠的后期阶段。 已知7-14 Hz振荡来自丘脑，并且有一些证据表明较慢的振荡也可能是丘脑振荡。然而，目前还不清楚丘脑的神经元是如何产生这些振荡的。在这项研究中，从一个年轻的物理学家，数学和计算建模研究这些节奏振荡将进行。丘脑和皮质之间的连接的作用和单个丘脑神经细胞的特性在产生 这些振荡将被检查。 这些理论研究应该提供对这些振荡的起源的见解，以及那些在感觉知觉期间发生在大脑中的振荡和那些与感觉知觉相关的振荡。 其他行为。