CAREER: Physiological Basis of Working Memory: Modeling of Prefontal Cortical Circuitry and its Neuromodulation

职业：工作记忆的生理学基础：前额皮质回路及其神经调节的建模

• 批准号: 9733006
• 负责人: Xiao-Jing Wang
• 金额: $ 45.14万
• 依托单位: Brandeis University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9733006&HistoricalAwards=false
• 关键词: CAREER; Physiological; Basis; Working; Memory

IBN 97-33006 WANG. Working memory is an active form of short-term memory. It is indispensable for any cognitive process where information has to be maintained with attentive effort for a few seconds, and manipulated "on-line", before it is erased and new information is loaded. Examples are dialing a telephone number, planning and executing a sequence of motor movements, reading, and thinking. Experiments on behaving animals have started to uncover the neuronal basis of working memory in the prefrontal cortex. Dr. Wang will use theoretical approaches, in complement with laboratory experiments, to investigate how the working memory function can be understood in terms of the physiology of single neurons/synapses, the cortical circuit architecture, and emergent collective network behavior. In particular, possible neuronal mechanisms will be studied by computer model simulations for sustained neuronal activity (in seconds) and its selectivity to memory items, including (a) reverberating activity across the cortical network, (b) slow cellular and synaptic dynamics, and (c) the role of recurrent synaptic inhibition. Results from this research will help to understand the functioning of normal working memory, its neuromodulation, as well as its malfunctions.

IBN 97-33006 WANG. 工作记忆是短期记忆的一种活跃形式。它对于任何认知过程都是必不可少的，在这些过程中，信息必须被集中精力保持几秒钟，并在被删除和加载新信息之前进行“在线”操作。例如，拨打电话号码，计划和执行一系列运动动作，阅读和思考。对有行为的动物进行的实验已经开始揭示前额叶皮层中工作记忆的神经基础。王博士将使用理论方法，与实验室实验相结合，研究如何从单个神经元/突触的生理学，皮层电路结构和紧急集体网络行为方面理解工作记忆功能。 特别是，将通过计算机模型模拟持续的神经元活动（以秒为单位）及其对记忆项目的选择性， (a)在大脑皮层网络中回响活动， (b)减缓细胞和突触动力学， (c)复发性突触抑制的作用。 这项研究的结果将有助于了解正常工作记忆的功能，其神经调节，以及它的故障。