Synthesis of Heterocyclic Natural Products

本研究的重点是开发Heck反应的变体，n -亚砜基亲二酚Diels-Alder方法和用于合成复杂天然产物的催化抗体技术。靶分子包括石蒜生物碱麦哲伦氨酸和麦哲伦胺酮，海洋生物碱圆柱精子素和agelastatin和天冬氨酸连接的碳水化合物。有了这个奖项，合成有机项目支持了宾夕法尼亚州立大学化学系的史蒂文·m·温莱布博士的研究。Weinreb教授将专注于开发具有生物学意义的复杂自然分子的全合成方法。

The focus of this research is the development of variants of the Heck reaction, N-sulfinyl dienophile Diels-Alder methodology and catalytic antibody technology for the synthesis of complex natural products. Target molecules include the Lycopodium alkaloids magellanine and magellaninone, the marine alkaloids cylindrospermopsin and agelastatin and asparganine-linked carbohydrates. With this award, the Synthetic Organic Program is supporting the research of Dr. Steven M. Weinreb of the Department Chemistry at Pennsylvania State University. Professor Weinreb will focus his work on the development of methodology for the total synthesis of complex naturally occurring molecules of biological significance.