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Inherited disorders of neuromuscular transmission in humans: understanding and manipulating molecular and cellular structure-function relationships at the motoneuron to muscle interface, the neuromuscular synapse, through a translational medicine approach

Inherited disorders of neuromuscular transmission in humans: understanding and manipulating molecular and cellular structure-function relationships at the motoneuron to muscle interface, the neuromuscular synapse, through a translational medicine approach
人类神经肌肉传递的遗传性疾病：通过转化医学方法理解和操纵运动神经元与肌肉界面（神经肌肉突触）的分子和细胞结构功能关系
批准号：
390300
负责人：
Lochmüller Hanns
金额：
$74.68万
依托单位：
Children's Hospital of Eastern Ontario- Ottawa Children's Treatment Centre
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2018
资助国家：
加拿大
项目状态：
已结题
起止时间：
2018-09-01 至 2022-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=390300&lang=en
关键词：
-Omics Animal Models Clinical Biomarkers Drug Repurposing Gene Discovery Genome-Wide Sequencing Molecular Pathways Neuromuscular Disease Rare Disease Translational Research

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中文摘要
翻译
人类肌肉的自由运动需要从脊髓中的神经细胞到帮助我们说话、进食、呼吸和行走的肌肉的电信号。这一过程被称为神经肌肉传递，可被中毒所损害。
英文摘要
Voluntary movement of muscles in humans requires electric signalling from the nerve cells in the spinal cord to the muscles that help us speak, eat, breathe and walk. This process, called neuromuscular transmission, can be impaired by poisoning, autoimmun
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会议论文
NMD4C: the neuromuscular network for Canada
Novel therapeutic approaches to target GNE Myopathy
NMD4C: An integrated research network for patients, scientists, and clinicians to improve outcomes and access to therapies for patients with neuromuscular disorders in Canada.
Canada Research Chair Tier 1
  • 批准号：
    392579
  • 项目类别：
  • 资助金额：
    $101.99万
  • 财政年份：
    2018
  • 负责人：
    Lochmüller Hanns
  • 依托单位：
    University of Ottawa
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