International Postdoctoral Fellows Program: Functional Analysis of the Coatomer Complex in the Secretory Pathway

9424028惠特尼国际初级研究员和博士后研究员计划使美国科学家和工程师能够在国外进行3至24个月的研究。该项目的奖项提供了联合研究的机会，并提供了使用国外独特或互补的设施、专业知识和实验条件的机会。该奖项将支持詹姆斯·安德鲁·惠特尼博士为期12个月的博士后研究访问，与瑞士日内瓦大学的托马斯·埃哈德·克雷斯教授合作。真核细胞的主要特征之一是由膜包裹的细胞器系统，新合成的分泌蛋白通过这些细胞器传递到细胞表面。膜蛋白和分泌蛋白在这些细胞器之间的转移通常涉及不同群体的运输囊泡的形成。了解这些转运事件的分子机制已经成为分子细胞生物学中最重要的问题之一。这项工作的主要目标是更多地了解分泌途径中小泡选择性萌发的分子机制。特别是，PI将使用相对较新的体内成像技术来跟踪被认为在这一过程中发挥作用的胞浆蛋白的动态分布。***

9424028 Whitney The International Junior Investigator and Postdoctoral Fellows Program enables U.S. scientists and engineers to conduct three to twenty-four months of research abroad. The program's awards provide opportunities for joint research, and the use of unique or complementary facilities, expertise and experimental conditions abroad. This award will support a twelve-month postdoctoral research visit by Dr. James Andrew Whitney to work with Professor Thomas Erhard Kreis at the University of Geneva in Switzerland. One of the defining features of eukaryotic cells is the system of membrane-enclosed organelles through which newly synthesized secretory proteins pass on their way to the cell surface. The transfer of membrane and secretory proteins between these organelles typically involves the formation of distinct populations of transport vesicles. Understanding the molecular mechanisms of these transport events has become one of the most important problems in molecular cell biology. The primary goal of the work proposed here is to learn more about the molecular mechanisms involved in the selective budding of vesicles in the secretory pathway. In particular, the PI will use relatively new in vivo imaging techniques to follow the dynamic distribution of cytosolic proteins thought to play a role in this process. ***