Design and Synthesis of Complexes for Catalytic, Enantioselective Conjugate Addition Reactions

本研究的重点是非稳定碳负离子(格氏试剂和二烷基锌试剂)对映体选择性1，4-加成α，β-不饱和羰基的催化剂的开发。研究内容包括三齿配体的合成，铜(I)和镍(II)配合物的制备和表征，以及作为不对称共轭加成催化剂的考察。教育计划的重点包括化学专业和非专业的教学，本科生和研究生参与实验室研究，以及积极参与外展。有了这一职业奖，合成有机计划将支持加州理工学院化学系Erick M.Carreira博士的研究和教育计划。Carreira教授将专注于手性碳-碳键形成催化剂的设计、合成和开发。卡雷拉教授的教育计划的重点包括化学专业和非专业的教学，本科生和研究生参与实验室研究，以及积极参与外展。

The focus of this research is the development of catalysts for enantioselective 1,4-additions of non-stabilized carbanions (Grignard and dialkylzinc reagents) to alpha,beta-unsaturated carbonyls. The investigation will involve the synthesis of tridentate ligands, preparation and characterization of Cu(I) and Ni(II) coordination complexes and the examination of the complexes as catalysts for asymmetric conjugate addition. The focus of the educational plan involves the teaching of both chemistry majors and non-majors,the involvement of undergraduates and graduate students in laboratory research and an active involvement in outreach. With this CAREER award, the Synthetic Organic Program is supporting the research and educational plan of Dr. Erick M. Carreira of the Department of Chemistry at the California Institute of Technology.Professor Carreira will focus his research efforts on the design, synthesis and development of catalysts for chiral carbon-carbon bond formation. The focus of Professor Carreira's educational plan involves the teaching of both chemistry majors and non-majors,the involvement of undergraduates and graduate students in laboratory research and an active involvement in outreach.