CAREER: Molecular Forces and Mechanisms Controlling Cell Adhesion

9503045 Leckband该项目的研究是通过直接测量控制这些事件的基本力和机制来阐明控制细胞附着到基质和其他细胞的基本相互作用。 这包括三个目标：（1）研究糖脂在蛋白质介导的细胞粘附中的作用;（2）研究鞘糖脂相互作用对细胞粘附的影响;（3）开发一种新的仪器，用于同时测量接近表面的光谱和力。 除了这项研究活动，首席研究员（PI）将加强教育，建立两个新的课程，在生物传感器和胶体，并通过引入计算机辅助教学工具到运输系列。 ***

9503045 Leckband This project is on research to elucidate the fundamental interactions governing cell attachment to substrata and to other cells by direct measurements of the fundamental forces and mechanisms controlling these events. This includes three objectives: (1) to investigate the role of glycolipids in protein-mediated cell adhesion; (2) to investigate the impact of glycosphingolipid interactions on cell adhesion; and (3) to develop a novel instrument for simultaneous spectral and force measurements for approaching surfaces. In addition to this research activity, the Principal Investigator (PI) will enhance education by establishing two new courses in biosensors and in colloids, and by introducing computer-aided instructional tools into the transport series. ***