Ultimate Sensitivity NMR of Liquids by Electron Nuclear Cross Polarization: A Pilot Study

在过去的35年里，液体高分辨率NMR的灵敏度前沿有了很大的进步。但由于样品浓度低于实际检测限，仍有许多重要问题不能用NMR解决。一种尚未开发的用于增加灵敏度的技术是电子-核交叉极化，其中电子共振的同时饱和增强核共振（在这种情况下，质子或碳共振）。这样的实验（基本上是同时进行的电子自旋共振和核磁共振实验）需要在NMR（或EPR）实验中通常不会遇到的仪器修改和对实验条件的仔细和精确的操作。由于这些极端的要求，必须证明这种方法的可行性。Bachovchin博士将进行这样的实验，以确定成功的可能性。

The frontier of sensitivity in high-resolution NMR of liquids has advanced greatly during the past 35 years. But there are still many important problems which cannot be solved by NMR because of sample concentrations falling below practical detection limits. One as yet unexploited technique for increasing sensitivity is that of electron - nuclear cross polarization in which the simultaneous saturation of an electron resonance enhances a nuclear resonance (in this case, a proton or carbon resonance). Such an experiment (essentially a simultaneous electron spin resonance and a nuclear magnetic resonance experiment) requires instrumental modifications not usually encountered in NMR (or in EPR) experiments and careful and precise manipulation of experimental conditions. Because of these extreme requirements the feasibility of such an approach must be demonstrated. Dr. Bachovchin will carry out such experiments to determine the possibility of success .