Conference: Large Scale Optimization, July 10 - 28, 1995 at the University of Minnesota, Minneapolis, MN

明尼苏达大学数学及其应用研究所将举行为期三周的会议，讨论大规模优化的分子最小化问题。 第三周将致力于分子和结构优化，特别是全球最小化问题。会议将汇集两个科学界（生物学、生物化学和生物物理学以及数学程序员），它们有很多问题要讨论，但尚未形成共同的语言和概念框架。将讨论的问题包括： 1.全局极小化算法的新进展 蛋白质折叠; 2.整体分子构象问题; 3.电阻抗断层成像; 4.具有多个局部极小值的问题; 5.电子化和高性能的使用 电脑 这些讨论将试图（I）从实践者的角度确定确切的物理问题;（ii）确定解决这些问题的可用方法;以及从长远来看（iii）缩小两者之间的差距。

The Institute for Mathematics and its Applications at the University of Minnesota will hold a three week conference on Molecular Minimization Aspects of Large-Scale Optimization. The third week will be devoted to molecular and structural optimization, in particular, the global minimization problem. The conference will bring together two scientific communities (the biological, biochemical and biophysical and the mathematical programmers) which have much to discuss together but have yet to develop a common language and conceptual framework. Issues which will be addressed include: 1. New algorithmic advances for global minimization in protein folding; 2. Global molecular conformation problems; 3. Electrical impedance tomography; 4. Problems with multiple local minima; and 5. Parallelization and the use of high performance computers. The discussions will attempt to (I) identify the precise physical problems from the practioners point of view; (ii) determine the available methods for attacking these problems; and, in the long term (iii) narrow the gap between the two.