NMR Instrumentation for Marine Natural Products Chemistry

这项来自化学研究仪器项目的奖励将帮助加州大学圣地亚哥分校化学系获得高性能300 MHz核磁共振，该核磁共振将用于以下化学领域的研究调查：海绵-裸枝关系的化学；共生体在海洋天然产物生产中的作用；影响高尔基体膜和抑制细胞内蛋白质运输的海洋天然产物；细胞毒性和抗生素海洋天然产物的发现；海洋无脊椎动物的抗炎剂；海洋生物的化学防御。核磁共振（NMR）波谱是化学家用来阐明分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。获得最先进的核磁共振光谱是必不可少的化学家谁正在进行前沿研究。这些核磁共振研究的结果在聚合物和催化以及生物学等领域都很有用。

This award from the Chemistry Research Instrumentation Program will help the Department of Chemistry at the University of California at San Diego to acquire a high performance 300 MHz NMR that will be used in research investigations in the following areas of chemistry: the chemistry of sponge-nudibranch relationships; the role of symbionts in the production of marine natural products; marine natural products that affect Golgi membranes and inhibit intracellular protein transport; the discovery of cytotoxic and antibiotic marine natural products; anti-inflammatory agents from marine invertebrates; and, chemical defense in marine organisms. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in areas such as polymers and catalysis, and in biology.