1996 Gordon Conference: Isotopes in Biology and Chemistry to be held in Ventura, California, February 11-16, 1996

9527873要求为将于1996年2月11日至16日在加利福尼亚州文图拉举行的生物和化学中的同位素戈登研究会议提供部分支助。这一由来已久的会议传统上聚集了来自多个学科(例如，物理化学和有机化学、大气化学和生物化学)的研究人员。由于其跨学科性质，该会议成为生物科学中产生新概念和新方法的温床。例如，20世纪80年代S在酶动力学方面取得了显著进展：认识到核隧穿在酶反应中的可能作用；促进了对磁场效应在酶反应中作用的系统研究；利用重原子同位素效应探索植物生理和进化；等等。这一趋势反映在当前的计划中，范围从讨论氢转移催化的新方面(低势垒氢键、隧道作用和质子池在催化中的作用)到使用同位素探针来建立和表征生物过程中的自由基物种。特别会议将专门审议重原子效应在表征生物系统方面的最新应用。在这个项目中将混合物理化学和反应机理的课程。这次会议的一个特别强大的组成部分是，它为理论家和实验家之间的互动提供了一种形式。%的同位素在生物和化学中被广泛使用，以便跟踪过程和了解功能。这次会议旨在将以跨学科方式使用同位素的科学家聚集在一起，以加强信息交流，并允许接触到新的结果。使生物学家接触到同位素的化学应用，对生化示踪方法学的发展尤为重要。***

9527873 Klinman Partial support is requested for the Gordon Research Conference on Isotopes in Biology and Chemistry to be held in Ventura, California, February 11-16, 1996. This long-standing conference has traditionally brought together investigators from a multitude of disciplines (e.g., physical and organic chemistry, atmospheric chemistry, and biological chemistry). As a result of its interdisciplinary nature, the Conference has served as a breeding ground for the generation of new concepts and methodologies in the biological sciences. Examples include the remarkable advances in enzymes kinetics that occurred in the 1980's: the recognition of the possible role of nuclear tunneling in enzyme reactions; the stimulation of a systematic study of the role of magnetic field effects in enzymatic reactions; the use of heavy atom isotope effects to probe plant physiology and evolution; etc. In recent years, the Conference has been moving increasingly into the area of biological chemistry. This trend is reflected in the current program which will range from a discussion of new aspects of H-transfer catalysis (low barrier hydrogen bonds, tunneling, and the role of proton pools in catalysis) to the use of isotopic probes to establish and characterize radical species in biological processes. A special session will be dedicated to a consideration of recent applications of heavy atom effects to characterize biological systems. Intermixed within this program will be sessions on both physical chemistry and reaction mechanisms. One particularly strong component of this conference is that it provides a format for the interaction of theoreticians with experimentalists. %%% Isotopes are widely used in biology and chemistry in order to follow processes and to understand function. This conference seeks to bring together scientists who use isotopes in an interdisciplinary manner in order to improve information exchange and allow exposure to new results. It is particularly important to the developm ent of biochemical tracer methodology that biologists be exposed to chemical applications of isotopes. ***