Coordinating gene expression and cell size: the role of feedback regulation

本项目旨在揭示人类细胞如何在单细胞水平上协调信使RNA （mRNA）转录物的产生、加工和降解动力学。它希望通过结合遗传学、单分子成像、数学建模和定量细胞生物学方面的创新跨学科研究方法，产生重要的基因调控生物学新知识。预期的结果包括加强对研究人员的培训，并在快速发展的RNA生物学和高通量显微镜领域建立澳大利亚的能力。这将为包括卫生、农业和兽医科学在内的无数应用提供显著的好处。

This project aims to reveal how human cells coordinate the kinetics of messenger RNA (mRNA) transcript production, processing and degradation at the single-cell level. It expects to generate significant new biological knowledge of gene regulation by combining innovative interdisciplinary research methodologies in genetics, single-molecule imaging, mathematical modelling and quantitative cell biology. Expected outcomes include enhanced training of researchers and to build Australia’s capability in the rapidly expanding fields of RNA biology and high-throughput microscopy. This should provide significant benefits for a myriad of applications including health, agriculture and veterinary sciences.